NMR structure note: the ferrous iron transport protein C (FeoC) from Klebsiella pneumoniae
Kuo-Wei Hung, Tzu-hsuan Juan, Yen-lan Hsu, Tai Huang Huang
Iron is an essential nutrient involved in many important biological processes ranging from electron transfer, oxygen transport, gene regulation, photosynthesis, N2 ﬁxation to DNA biosynthesis (Andrews et al. 2003). Thus, the ability to acquire sufﬁcient quantities of iron from the environment is vital for the survival of living organisms. This is particularly true for pathogens that must compete with the host iron-withdrawal response for their iron supplies. However, iron is also toxic and excess iron can be detrimental for the living system (Touati 2000). It is, therefore, essential for almost all life forms to maintain proper iron homeostasis (Andrews et al. 2003).